Collagenase digestion down-regulates the density of CD27 on lymphocytes.

  title={Collagenase digestion down-regulates the density of CD27 on lymphocytes.},
  author={Zhangbo Chen and Xiangyu Chen and Yong Xu and Ping Xiong and M. T. Fang and Zheng Jie Tan and Feili Gong and Fang Zheng},
  journal={Journal of immunological methods},
Collagenases are widely used for tissue digestion in experiments due to their potent hydrolysis of connective tissue. CD27, also known as tumor necrosis factor receptor superfamily 7 (TNFRSF7), is limited to be expressed on the cells of the lymphoid lineage. In our preliminary research, we found that CD27 on NK cells was almost disappeared with the digestion of type I collagenase for 90min. This phenomenon suggests that the process of tissue digestion may affect the density of CD27 on cells. In… CONTINUE READING
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