Collagenase-3 expression in breast myofibroblasts as a molecular marker of transition of ductal carcinoma in situ lesions to invasive ductal carcinomas.

@article{Nielsen2001Collagenase3EI,
  title={Collagenase-3 expression in breast myofibroblasts as a molecular marker of transition of ductal carcinoma in situ lesions to invasive ductal carcinomas.},
  author={Boye Schnack Nielsen and Fritz Rank and Jesus Maria Lopez and Milagros Balb{\'i}n and Francisco J Vizoso and Leif R\oge Lund and Keld Dan\o and Carlos L{\'o}pez-Ot{\'i}n},
  journal={Cancer research},
  year={2001},
  volume={61 19},
  pages={7091-100}
}
Collagenase-3 (matrix metalloproteinase 13; MMP-13), a protease originally identified in breast carcinoma, is characterized by a potent degrading activity against a wide spectrum of extracellular matrix proteins. The aims of this study were to localize and identify the MMP-13-expressing cells in invasive human breast carcinoma and to evaluate the role of MMP-13 in transition to invasive lesions by studying ductal carcinoma in situ (DCIS). We found expression of MMP-13 in stromal fibroblast-like… CONTINUE READING
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