Collagenase-2 (matrix metalloproteinase-8) plays a protective role in tongue cancer

@article{Korpi2008Collagenase2M,
  title={Collagenase-2 (matrix metalloproteinase-8) plays a protective role in tongue cancer},
  author={Jarkko T Korpi and V Kervinen and H M{\"a}klin and Anu V{\"a}{\"a}n{\"a}nen and Minna Lahtinen and Esa L{\"a}{\"a}r{\"a} and Ari Ristim{\"a}ki and George Thomas and Merja Ylipalosaari and Pirjo {\AA}str{\"o}m and Carlos L{\'o}pez-Ot{\'i}n and Timo Sorsa and Saara Kantola and Emma M Piril{\"a} and Tuula Salo},
  journal={British Journal of Cancer},
  year={2008},
  volume={98},
  pages={766 - 775}
}
Squamous cell carcinoma (SCC) of the tongue is the most common cancer in the oral cavity and has a high mortality rate. A total of 90 mobile tongue SCC samples were analysed for Bryne's malignancy scores, microvascular density, and thickness of the SCC sections. In addition, the staining pattern of cyclooxygenase-2, αvβ6 integrin, the laminin-5 γ2-chain, and matrix metalloproteinases (MMPs) -2, -7, -8, -9, -20, and -28 were analysed. The expression of MMP-8 (collagenase-2) was positively… CONTINUE READING
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