Collagenase-1 injection improved tumor distribution and gene expression of cationic lipoplex.

@article{Kato2012Collagenase1II,
  title={Collagenase-1 injection improved tumor distribution and gene expression of cationic lipoplex.},
  author={Mako Kato and Yoshiyuki Hattori and Manami Kubo and Yoshie Maitani},
  journal={International journal of pharmaceutics},
  year={2012},
  volume={423 2},
  pages={428-34}
}
Elevated interstitial fluid pressure (IFP) in a tumor is a barrier to tumor accumulation of systemic delivery of nanocarriers. In this study, we investigated whether intravenous injection of type I collagenase (collagenase-1) reduced IFP in tumors and increased the accumulation and gene expression of cationic liposome/plasmid DNA complex (lipoplex) in tumors after intravenous injection into mice bearing mouse lung carcinoma LLC tumors. Collagenase-1 reduced the amount of type I collagen in the… CONTINUE READING

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