Collagenase-1 injection improved tumor distribution and gene expression of cationic lipoplex.

  title={Collagenase-1 injection improved tumor distribution and gene expression of cationic lipoplex.},
  author={Mako Kato and Yoshiyuki Hattori and Manami Kubo and Yoshie Maitani},
  journal={International journal of pharmaceutics},
  volume={423 2},
Elevated interstitial fluid pressure (IFP) in a tumor is a barrier to tumor accumulation of systemic delivery of nanocarriers. In this study, we investigated whether intravenous injection of type I collagenase (collagenase-1) reduced IFP in tumors and increased the accumulation and gene expression of cationic liposome/plasmid DNA complex (lipoplex) in tumors after intravenous injection into mice bearing mouse lung carcinoma LLC tumors. Collagenase-1 reduced the amount of type I collagen in the… CONTINUE READING

From This Paper

Topics from this paper.


Publications citing this paper.
Showing 1-10 of 16 extracted citations

Bacterial collagenases - A review.

Critical reviews in microbiology • 2016
View 6 Excerpts
Highly Influenced

Tumour tissue transport after intraperitoneal anticancer drug delivery.

International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group • 2017
View 1 Excerpt

Increased fibrosis and impaired intratumoral accumulation of macromolecules in a murine model of pancreatic cancer co-administered with FGF-2.

Journal of controlled release : official journal of the Controlled Release Society • 2016
View 2 Excerpts

Similar Papers

Loading similar papers…