Collagenase (MMP-1) and TIMP-1 in destructive corneal disease associated with rheumatoid arthritis

@article{Riley1995CollagenaseA,
  title={Collagenase (MMP-1) and TIMP-1 in destructive corneal disease associated with rheumatoid arthritis},
  author={Graham J. P. Riley and Rebecca L. Harrall and Peter G Watson and Timothy E Cawston and Brian L. Hazleman},
  journal={Eye},
  year={1995},
  volume={9},
  pages={703-718}
}
The aim of the study was to immunolocalise interstitial collagenase (MMP-1) and the tissue inhibitor of metalloproteinases (TIMP-1) in ulcerating corneas from patients with rheumatoid arthritis, to determine whether changes in expression are associated with destructive corneal disease. Collagenase was expressed by stromal cells in 8 of 8 ulcerating corneas but was not seen in normal tissue (n = 3). TIMP-1 was abundant throughout the normal stroma, but was much reduced or absent from diseased… CONTINUE READING

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