Collagen type II, alpha 1 protein: a bioactive component of shark cartilage.

@article{Merly2013CollagenTI,
  title={Collagen type II, alpha 1 protein: a bioactive component of shark cartilage.},
  author={Liza Merly and Sylvia L. Smith},
  journal={International immunopharmacology},
  year={2013},
  volume={15 2},
  pages={
          309-15
        }
}
Previous studies have shown that extracts of shark cartilage induce a cytokine response in human leukocytes, but the nature of the bioactive component(s) is unknown. Extracts treated with proteases lost 80% of their cytokine-inducing property, suggesting that the active component(s) was likely a complex protein. The aim of the present study was to determine the nature of the bioactive molecule(s). Solid phase extraction followed by ion exchange chromatography and electrophoretic separation were… CONTINUE READING
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