Collagen tube lined with genetically modified Schwann cells with increased motility: A new promising bioartificial nerve graft

@article{Gravvanis2005CollagenTL,
  title={Collagen tube lined with genetically modified Schwann cells with increased motility: A new promising bioartificial nerve graft},
  author={Andreas I. Gravvanis and Alexandros Α. Lavdas and Apostolos E Papalois and Dimosthenis A Tsoutsos and Petros N. Panayotou and D. C.-C. Chuang and Isabelle Franceschini and Monique Dubois-Dalcq and Rebecca Matsas},
  journal={European Surgery},
  year={2005},
  volume={37},
  pages={204-212}
}
BACKGROUND: In the present study we designed a new artificial nerve graft consisting of a type I collagen tube lined with sialyl-transferase-X-transduced Schwann cells (SC), with increased motility, and investigated its efficacy in bridging nerve gaps in the rat sciatic nerve model. METHODS: One hundred and twenty male Wistar rats were randomized in 4 groups of 30. A defect, 12 mm long in the left sciatic nerve, was created and repaired in an end-to-end fashion with a nerve autograft (group A… CONTINUE READING
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