Collagen synthesis by bone marrow stromal cells: a quantitative study.

  title={Collagen synthesis by bone marrow stromal cells: a quantitative study.},
  author={Sharon Ann Bentley},
  journal={British journal of haematology},
  volume={50 3},
Collagen-producing, marrow-derived adherent cells (MDAC) provide a microenvironment which supports haemopoietic stem cell (HSC) proliferation in vitro. To investigate the relationship between collagen-producing cells in intact marrow and in MDAC cultures, quantitative studies of collagen synthesis were performed. Collagen synthesis by fresh murine bone marrow cells was 0.22% of total protein synthesis and collagen types I and III were synthesized in a ratio of approximately 5:1. During MDAC… CONTINUE READING

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