Collagen structure regulates fibril mineralization in osteogenesis as revealed by cross-link patterns in calcifying callus.

@article{Wassen2000CollagenSR,
  title={Collagen structure regulates fibril mineralization in osteogenesis as revealed by cross-link patterns in calcifying callus.},
  author={Maurice H M Wassen and J. M. G. Lammens and J M Tekoppele and R. Sakkers and Zhaowei Liu and Ab J. Verbout and Ruud A. Bank},
  journal={Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research},
  year={2000},
  volume={15 9},
  pages={1776-85}
}
Although >80% of the mineral in mammalian bone is present in the collagen fibrils, limited information is available about factors that determine a proper deposition of mineral. This study investigates whether a specific collagen matrix is required for fibril mineralization. Calcifying callus from dog tibias was obtained at various times (3-21 weeks) after fracturing. At 3 weeks, hydroxylysine (Hyl) levels were almost twice as high as in control bone, gradually reaching normal levels at 21 weeks… CONTINUE READING
17 Citations
0 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 17 extracted citations

Similar Papers

Loading similar papers…