Collagen scaffolds for orthopedic regenerative medicine

@article{Cunniffe2011CollagenSF,
  title={Collagen scaffolds for orthopedic regenerative medicine},
  author={Gr{\'a}inne M. Cunniffe and Fergal Joseph O'Brien},
  journal={JOM},
  year={2011},
  volume={63},
  pages={66-73}
}
Collagen and collagen-based scaffolds offer distinct advantages when selected as biomaterials for use across a broad spectrum of regenerative medicine applications. However, relatively poor mechanical properties are often perceived to limit their usefulness for orthopedic applications. These problems can be overcome through enhanced crosslinking mechanisms or through the addition of a second, stiffer phase such as hydroxyapatite, thus allowing tailored composite scaffolds to meet specific… 
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Collagen-based biomaterials for tissue regeneration and repair
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Collagen-based scaffolds were developed with different concentrations and processing techniques, by obtaining hydrogels and aerogels that were characterized with an emphasis on their morphology and mechanical properties, and revealed that the scaffolds with higher collagen concentrations were more rigid and deformable.
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