Collagen scaffold enhances the regenerative properties of mesenchymal stromal cells

@inproceedings{Rashedi2017CollagenSE,
  title={Collagen scaffold enhances the regenerative properties of mesenchymal stromal cells},
  author={Iran Rashedi and Nilesh P Talele and Xing-Hua Wang and Boris Hinz and Milica Radisic and Armand Keating},
  booktitle={PloS one},
  year={2017}
}
MSCs are widely applied to regenerate heart tissue in myocardial diseases but when grown in standard two-dimensional (2D) cultures exhibit limited potential for cardiac repair and develop fibrogenic features with increasing culture time. MSCs can undergo partial cardiomyogenic differentiation, which improves their cardiac repair capacity. When applied to collagen patches they may improve cardiac tissue regeneration but the mechanisms remain elusive. Here, we investigated the regenerative… CONTINUE READING

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