Collagen phagocytosis by lung alveolar macrophages in animal models of emphysema.

@article{Lucattelli2003CollagenPB,
  title={Collagen phagocytosis by lung alveolar macrophages in animal models of emphysema.},
  author={Monica Lucattelli and Eleonora Cavarra and Maria Margherita de Santi and Teresa D. Tetley and Piero Antonio Martorana and Giuseppe Lungarella},
  journal={The European respiratory journal},
  year={2003},
  volume={22 5},
  pages={
          728-34
        }
}
Under steady state conditions the intracellular pathway is the major route of collagen catabolism in tissues characterised by rapid collagen turnover. In the lung, the collagen is subject to continuous remodelling and turnover however, the intracellular pathway of collagen degradation is unusual under physiological conditions. The current authors previously described crystalloid inclusions in alveolar macrophages of mice with genetic emphysema at the time of septal disruption. Using an… CONTINUE READING

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