Collagen oligomers modulate physical and biological properties of three-dimensional self-assembled matrices.

@article{Bailey2011CollagenOM,
  title={Collagen oligomers modulate physical and biological properties of three-dimensional self-assembled matrices.},
  author={James L. Bailey and Paul John Critser and Catherine F. Whittington and Joanne L Kuske and Mervin C. Yoder and Sherry L Voytik-Harbin},
  journal={Biopolymers},
  year={2011},
  volume={95 2},
  pages={
          77-93
        }
}
Elucidation of mechanisms underlying collagen fibril assembly and matrix-induced guidance of cell fate will contribute to the design and expanded use of this biopolymer for research and clinical applications. Here, we define how Type I collagen oligomers affect in-vitro polymerization kinetics as well as fibril microstructure and mechanical properties of formed matrices. Monomers and oligomers were fractionated from acid-solubilized pig skin collagen and used to generate formulations varying in… CONTINUE READING

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