Collagen nerve conduits releasing the neurotrophic factors GDNF and NGF.

  title={Collagen nerve conduits releasing the neurotrophic factors GDNF and NGF.},
  author={Srinivas Madduri and Kirill Feldman and Theo A. Tervoort and Micha{\"e}l Y Papalo{\"i}zos and Bruno A Gander},
  journal={Journal of controlled release : official journal of the Controlled Release Society},
  volume={143 2},
Artificial nerve conduits (NC) can clinically be instrumental for facilitating the surgery of damaged peripheral nerves. To improve axonal regeneration of injured peripheral nerves, we have developed collagen nerve conduits (NC) releasing glial cell line-derived neurotrophic factor (GDNF) alone or in combination with nerve growth factor (NGF), which exert synergistic action on axonal growth. Degradation of the NC and their mechanical and drug release properties were controlled by two means: (i… CONTINUE READING
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