Collagen nanofibres are a biomimetic substrate for the serum-free osteogenic differentiation of human adipose stem cells.

@article{Sefcik2008CollagenNA,
  title={Collagen nanofibres are a biomimetic substrate for the serum-free osteogenic differentiation of human adipose stem cells.},
  author={Lauren S Sefcik and Rebekah A. Neal and Stephanie N Kaszuba and Anna M Parker and Adam J. Katz and Roy C Ogle and Edward A. Botchwey},
  journal={Journal of tissue engineering and regenerative medicine},
  year={2008},
  volume={2 4},
  pages={210-20}
}
Electrospinning has recently gained widespread attention as a process capable of producing nanoscale fibres that mimic native extracellular matrix. In this study, we compared the osteogenic differentiation behaviour of human adipose stem cells (ASCs) on a 3D nanofibre matrix of type I rat tail collagen (RTC) and a 2D RTC collagen-coated substrate, using a novel serum-free osteogenic medium. The serum-free medium significantly enhanced the numbers of proliferating cells in culture, compared to… CONTINUE READING