Collagen molecules comprised of alpha 1(V)-chains (B-chains): an apparent localization in the exocytoskeleton.

Abstract

Antibodies specific for alpha 1(V) chains and native collagen molecules containing the alpha 1(V) chain have been used to study the localization of alpha 1(V)-containing molecules in differentiating hyaline cartilage. Immunofluorescence data show that the undifferentiated mesenchyme contains significant quantities of these molecules throughout the cell-rich tissue matrix. Examination of fully differentiated hyaline cartilage reveals a unique staining pattern wherein the immunofluorescent material is restricted to the pericellular matrix within the chondrocyte lacunae. We conclude from these data in conjunction with other evidence that the Type V collagens function as components of an exocytoskeleton for connective tissue cells.

Statistics

0100200300'82'85'89'93'97'01'05'09'13'17
Citations per Year

459 Citations

Semantic Scholar estimates that this publication has 459 citations based on the available data.

See our FAQ for additional information.

Cite this paper

@article{Gay1981CollagenMC, title={Collagen molecules comprised of alpha 1(V)-chains (B-chains): an apparent localization in the exocytoskeleton.}, author={Steffen Gay and Rathbun K Rhodes and R E Gay and Edward Miller}, journal={Collagen and related research}, year={1981}, volume={1 1}, pages={53-8} }