Collagen molecules: distribution of alpha chains.

@article{Nold1970CollagenMD,
  title={Collagen molecules: distribution of alpha chains.},
  author={J G Nold and Andrew Kang and Jerome Gross},
  journal={Science},
  year={1970},
  volume={170 3962},
  pages={1096-8}
}
To ascertain the distribution of alpha chains within the collagen molecule, intramolecular cross-links were introduced into tropocollagen by reacting formaldehyde with dilute homogeneous molecular dispersions of collagen extracted from lathyritic guinea pig skin. Denaturation, chromatography on carboxymethyl cellulose, measurement of molecular weight, and analyses of the amino acids of the cross-linked product indicate that most, if not all, of the collagen molecules consist of two alpha1… CONTINUE READING

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