Collagen metabolism is a novel target of the neuropeptide alpha-melanocyte-stimulating hormone.

@article{Bhm2004CollagenMI,
  title={Collagen metabolism is a novel target of the neuropeptide alpha-melanocyte-stimulating hormone.},
  author={Markus B{\"o}hm and Michael Raghunath and Cord Sunderkoetter and Meinhard Schiller and Sonja St{\"a}nder and Thomas Brzoska and Thomas Cauvet and Helgi B. Schi{\"o}th and Thomas Schwarz and Thomas Anton Luger},
  journal={The Journal of biological chemistry},
  year={2004},
  volume={279 8},
  pages={6959-66}
}
Suppression of collagen synthesis is a major therapeutic goal in the treatment of fibrotic disorders. We show here that alpha-melanocyte-stimulating hormone (alpha-MSH), a neuropeptide well known for its pigment-inducing capacity, modulates collagen synthesis and deposition. Alpha-MSH in vitro suppresses the synthesis of collagen types I, III, and V and down-regulates the secretion of procollagen type I C-terminal peptide (PICP) in human dermal fibroblasts treated with the fibrogenic cytokine… CONTINUE READING

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