Collagen-induced arthritis in nonhuman primates: multiple epitopes of type II collagen can induce autoimmune-mediated arthritis in outbred cynomolgus monkeys.

Abstract

OBJECTIVE To define which regions of the type II collagen (CII) molecule result in anticollagen antibody production and the subsequent development of autoantibodies in a collagen-induced arthritis (CIA) nonhuman primate model. METHODS Male and female cynomolgus monkeys (2-6 of each sex per group) were immunized with either chicken (Ch), human, or monkey… (More)

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@article{Shimozuru1998CollageninducedAI, title={Collagen-induced arthritis in nonhuman primates: multiple epitopes of type II collagen can induce autoimmune-mediated arthritis in outbred cynomolgus monkeys.}, author={Yasunori Shimozuru and Shigeru Yamane and Kiyohide Fujimoto and K. Terao and Satoshi Honjo and Y. Nagai and Allen Dale Sawitzke and Kuniaki Terato}, journal={Arthritis and rheumatism}, year={1998}, volume={41 3}, pages={507-14} }