Collagen-induced arthritis, an animal model of autoimmunity.

  title={Collagen-induced arthritis, an animal model of autoimmunity.},
  author={Linda Myers and Edward F. Rosloniec and M. A. Cremer and Andrew Kang},
  journal={Life sciences},
  volume={61 19},
Collagen induced arthritis (CIA) is an autoimmune model that in many ways resembles rheumatoid arthritis (RA). Immunization of genetically susceptible strains of rodents and primates with type II collagen (CII) leads to the development of a severe polyarticular arthritis that is mediated by an autoimmune response. Like RA, synovitis and erosions of cartilage and bone are hallmarks of CIA, and susceptibility to both RA and CIA is linked to the expression of specific MHC class II molecules… CONTINUE READING


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