Collagen hydrolysate for the treatment of osteoarthritis and other joint disorders:a review of the literature

@article{Bello2006CollagenHF,
  title={Collagen hydrolysate for the treatment of osteoarthritis and other joint disorders:a review of the literature},
  author={Alfonso E. Bello and Steffen Oesser},
  journal={Current Medical Research and Opinion},
  year={2006},
  volume={22},
  pages={2221 - 2232}
}
BACKGROUND There is a need for an effective treatment for the millions of people in the United States with osteoarthritis (OA), a degenerative joint disease. [...] Key Method Articles were obtained through searches of the PubMed database (www.pubmed.gov) through May 2006 using several pairs of key words (collagen hydrolysate and osteoarthritis; collagen hydrolysate and cartilage; collagen hydrolysate and chondrocytes; collagen hydrolysate and clinical trial) without date limits.Expand
POTENCY OF ORAL UN-DENATURED TYPE II COLLAGENIN THE TREATMENT OF OSTEOARTHRITIS, WITH SPECIFICAL RELATIONSHIP TO KNEE JOINT- A META-ANALYTIC REVIEW
Introduction: One of the chronic progressive diseases of the elderly is Osteoarthritis. There is a wide spectrum of Nutraceuticals, for Osteoarthritis, but there does not exist, a convincingExpand
Role of Collagen Derivatives in Osteoarthritis and Cartilage Repair: A Systematic Scoping Review With Evidence Mapping
TLDR
Although current evidence shows some potential for the use of CH and UC as an option for management of patients with OA, there is still room for progress in terms of laboratory and clinical research before any definitive conclusion can be made. Expand
Symptomatic and chondroprotective treatment with collagen derivatives in osteoarthritis: a systematic review.
TLDR
There is insufficient evidence to recommend the generalized use of CHs in daily practice for the treatment of patients with OA, and more independent high-quality studies are needed to confirm the therapeutic effects of collagen derivatives on OA complaints. Expand
[An overview of the beneficial effects of hydrolysed collagen intake on joint and bone health and on skin ageing].
TLDR
Clinical studies show that HC continual ingestion helps to reduce and prevent joint pain, bone density loss and skin ageing, and its high level of tolerance and safety make HC ingestion attractive for a long-term use in bone and joint degenerative diseases and in fight against skin ageing. Expand
Collagen Metabolism of Human Osteoarthritic Articular Cartilage as Modulated by Bovine Collagen Hydrolysates
TLDR
It is found that various collagen hydrolysates obtained from different sources varied with respect to the width of molecular weight distribution, average molecular weight, and aggregation behavior, as well as by their pharmacological efficacy on human chondrocytes. Expand
Effect of the novel low molecular weight hydrolyzed chicken sternal cartilage extract, BioCell Collagen, on improving osteoarthritis-related symptoms: a randomized, double-blind, placebo-controlled trial.
TLDR
BCC was well tolerated and found to be effective in managing OA-associated symptoms over the study period, thereby improving patient's activities of daily living and can be considered a potential complement to current OA therapies. Expand
ect of the Novel Low Molecular Weight Hydrolyzed Chicken Sternal Cartilage Extract , BioCell Collagen , on Improving Osteoarthritis-Related Symptoms : A Randomized , Double-Blind , Placebo-Controlled Trial
Osteoarthritis (OA) is a significant source of pain and disability. Current medical and surgical treatments can be costly and have serious side effects. The aim of this randomized, double-blind,Expand
Impact of collagen hydrolysate in middle-aged athletes with knee and ankle osteochondral lesions: A case series
TLDR
MRI images of patients assessed in this study depict the recovery of the articular surfaces after the treatment of OCL, and studies in athletes presenting joint pain but otherwise not diagnosed with osteoarthritis or other osteoarticular diseases have demonstrated the beneficial effects of CH intake. Expand
24-Week study on the use of collagen hydrolysate as a dietary supplement in athletes with activity-related joint pain.
TLDR
This was the first clinical trial of 24-weeks duration to show improvement of joint pain in athletes who were treated with the dietary supplement collagen hydrolysate and the primary efficacy parameter was the change in the visual analogue scales from baseline during the study phase. Expand
24-Week study on the use of collagen hydrolysate as a dietary supplement in athletes with activity-related joint pain
TLDR
The primary efficacy parameter was the change in the visual analogue scales from baseline during the study phase in relation to the parameters referring to pain, mobility, and inflammation, which showed statistically significant changes with the dietary supplement collagen hydrolysate. Expand
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TLDR
Collagen hydrolysate is of interest as a therapeutic agent of potential utility in the treatment of osteoarthritis and osteoporosis, and its high level of safety makes it attractive as an agent for long-term use in these chronic disorders. Expand
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TLDR
Evaluation of benefit of glucosamine and chondroitin preparations for OA symptoms using meta-analysis combined with systematic quality assessment of clinical trials of these preparations in knee and/or hip OA suggests some degree of efficacy appears probable for these preparations. Expand
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Advocates of these alternative modalities cite reports of progressive and gradual decline of joint pain and tenderness, improved mobility, sustained improvement after drug withdrawal, and a lack of significant toxicity associated with short-term use of these agents. Expand
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TLDR
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TLDR
The evidence to date suggests that NSAIDs are superior to acetaminophen for improving knee and hip pain in people with OA but have not been shown to be superior in improving function. Expand
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TLDR
These multifunctional fibroblast-like chondrocytes could present an ideal therapeutic starting point if they could be modified to synthesize the collagen type II typical for cartilage and to contribute to reversing the damage of the joint cartilage that has occurred by the late stages of osteoarthritis. Expand
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TLDR
Non steroidal antiinflammatory drugs (NSAD) inhibit either protein and sulfated mucopolysaccharides (SMPS) synthesis in agreement with previously reported data in favour of a common control mechanism for both synthesis. Expand
Glucosamine, chondroitin sulfate, and the two in combination for painful knee osteoarthritis.
TLDR
Exploratory analyses suggest that the combination of glucosamine and chondroitin sulfate may be effective in the subgroup of patients with moderate-to-severe knee pain, and the efficacy and safety of these treatments as a treatment for knee pain from osteoarthritis are evaluated. Expand
Efficacy of methylsulfonylmethane (MSM) in osteoarthritis pain of the knee: a pilot clinical trial.
TLDR
The benefits and safety of MSM in managing OA and long-term use cannot be confirmed from this pilot trial, but its potential clinical application is examined. Expand
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