Collagen hydrolysate for the treatment of osteoarthritis and other joint disorders:a review of the literature

  title={Collagen hydrolysate for the treatment of osteoarthritis and other joint disorders:a review of the literature},
  author={Alfonso E. Bello and Steffen Oesser},
  journal={Current Medical Research and Opinion},
  pages={2221 - 2232}
  • A. BelloS. Oesser
  • Published 10 October 2006
  • Medicine
  • Current Medical Research and Opinion
BACKGROUND There is a need for an effective treatment for the millions of people in the United States with osteoarthritis (OA), a degenerative joint disease. [] Key Method Articles were obtained through searches of the PubMed database ( through May 2006 using several pairs of key words (collagen hydrolysate and osteoarthritis; collagen hydrolysate and cartilage; collagen hydrolysate and chondrocytes; collagen hydrolysate and clinical trial) without date limits.

Effect of hydrolysed collagen supplementation on knee osteoarthritis: a systematic review

It is demonstrated that in long-term inflammatory diseases, anti-inflammatory drugs had a slightly superior effect compared to placebo and oral supplementation with hydrolysed collagen supplementation may be slightly effective to mitigate KOA symptoms.


Type II Undenatured Collagen, is a relatively safe and also signicantly more efcient, in improving the joint function, ROM and for the alleviation of bone joint pain, in OA knee (Genu OA) patients.

Role of Collagen Derivatives in Osteoarthritis and Cartilage Repair: A Systematic Scoping Review With Evidence Mapping

Although current evidence shows some potential for the use of CH and UC as an option for management of patients with OA, there is still room for progress in terms of laboratory and clinical research before any definitive conclusion can be made.

A White Paper on Collagen Hydrolyzates and Ultrahydrolyzates: Potential Supplements to Support Joint Health in Osteoarthritis?

This White Paper aims to stimulate research and development of collagen-based supplements for patients with OA and other musculoskeletal diseases at academic and industrial levels and highlight opportunities for scientific innovation and interdisciplinary collaboration.

The effects of collagen peptide supplementation on body composition, collagen synthesis, and recovery from joint injury and exercise: a systematic review

The results indicated that COL is most beneficial in improving joint functionality and reducing joint pain, and certain improvements in body composition, strength and muscle recovery were present.

Therapeutic Activity of Collagen and Rosehip Extracts: A Review

Options for therapeutic activity of hydrolysate are explored for the treatment of osteoarthritis and other joint disorders and as a dietary supplement in athletes with activity-related joint pain.

[An overview of the beneficial effects of hydrolysed collagen intake on joint and bone health and on skin ageing].

Clinical studies show that HC continual ingestion helps to reduce and prevent joint pain, bone density loss and skin ageing, and its high level of tolerance and safety make HC ingestion attractive for a long-term use in bone and joint degenerative diseases and in fight against skin ageing.

Collagen Metabolism of Human Osteoarthritic Articular Cartilage as Modulated by Bovine Collagen Hydrolysates

It is found that various collagen hydrolysates obtained from different sources varied with respect to the width of molecular weight distribution, average molecular weight, and aggregation behavior, as well as by their pharmacological efficacy on human chondrocytes.

Effect of the novel low molecular weight hydrolyzed chicken sternal cartilage extract, BioCell Collagen, on improving osteoarthritis-related symptoms: a randomized, double-blind, placebo-controlled trial.

BCC was well tolerated and found to be effective in managing OA-associated symptoms over the study period, thereby improving patient's activities of daily living and can be considered a potential complement to current OA therapies.



Role of collagen hydrolysate in bone and joint disease.

  • R. Moskowitz
  • Medicine
    Seminars in arthritis and rheumatism
  • 2000
Collagen hydrolysate is of interest as a therapeutic agent of potential utility in the treatment of osteoarthritis and osteoporosis, and its high level of safety makes it attractive as an agent for long-term use in these chronic disorders.

Glucosamine and chondroitin for treatment of osteoarthritis: a systematic quality assessment and meta-analysis.

Evaluation of benefit of glucosamine and chondroitin preparations for OA symptoms using meta-analysis combined with systematic quality assessment of clinical trials of these preparations in knee and/or hip OA suggests some degree of efficacy appears probable for these preparations.

Use of glucosamine and chondroitin sulfate in the management of osteoarthritis.

  • E. ArnoldW. Arnold
  • Medicine
    The Journal of the American Academy of Orthopaedic Surgeons
  • 2001
Advocates of these alternative modalities cite reports of progressive and gradual decline of joint pain and tenderness, improved mobility, sustained improvement after drug withdrawal, and a lack of significant toxicity associated with short-term use of these agents.

Rofecoxib for rheumatoid arthritis.

Two randomised controlled trials evaluating rofecoxib for the treatment of RA demonstrated similar efficacy to naproxen at a dosage of 500 mg twice daily, however, the combined rate of clinically significant complicated gastro-intestinal events (GI) was lower with rofECoxib than with naproxens, due to a reduction in the number of ulcers and bleeds.

Acetaminophen for osteoarthritis.

The evidence to date suggests that NSAIDs are superior to acetaminophen for improving knee and hip pain in people with OA but have not been shown to be superior in improving function.

New aspects of the pathogenesis of osteoarthritis: the role of fibroblast-like chondrocytes in late stages of the disease.

These multifunctional fibroblast-like chondrocytes could present an ideal therapeutic starting point if they could be modified to synthesize the collagen type II typical for cartilage and to contribute to reversing the damage of the joint cartilage that has occurred by the late stages of osteoarthritis.

Glucosamine, chondroitin sulfate, and the two in combination for painful knee osteoarthritis.

Exploratory analyses suggest that the combination of glucosamine and chondroitin sulfate may be effective in the subgroup of patients with moderate-to-severe knee pain, and the efficacy and safety of these treatments as a treatment for knee pain from osteoarthritis are evaluated.

Do antioxidant micronutrients protect against the development and progression of knee osteoarthritis?

High intake of antioxidant micronutrients, especially vitamin C, may reduce the risk of cartilage loss and disease progression in people with OA, and no effect of antioxidant nutrients on incident OA is found.