Collagen gene expression and the altered accumulation of scleral collagen during the development of high myopia.

@article{Gentle2003CollagenGE,
  title={Collagen gene expression and the altered accumulation of scleral collagen during the development of high myopia.},
  author={Alex Gentle and Yanyan Liu and Jennifer M. Martin and Giada L Conti and Neville A. Mcbrien},
  journal={The Journal of biological chemistry},
  year={2003},
  volume={278 19},
  pages={16587-94}
}
The development of high myopia is associated with reduced scleral collagen accumulation, scleral thinning, and loss of scleral tissue, in both humans and animal models. Reduced collagen fibril diameter is also observed in the sclera of eyes with high myopia. The present study investigated aspects of scleral collagen synthesis and degradation, in a mammalian model of high myopia, to elucidate the factors underlying scleral changes. General synthesis and degradation of scleral collagen was… CONTINUE READING

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