Collagen fibrillogenesis in the development of the annulus fibrosus of the intervertebral disc.

@article{Hayes2011CollagenFI,
  title={Collagen fibrillogenesis in the development of the annulus fibrosus of the intervertebral disc.},
  author={A. Hayes and Marc D. Isaacs and C. Hughes and B. Caterson and J. Ralphs},
  journal={European cells \& materials},
  year={2011},
  volume={22},
  pages={
          226-41
        }
}
The annulus fibrosus of the intervertebral disc is a complex, radial-ply connective tissue consisting of concentric lamellae of oriented collagen. Whilst much is known of the structure of the mature annulus, less is known of how its complex collagenous architecture becomes established; an understanding of which could inform future repair/regenerative strategies. Here, using a rat disc developmental series, we describe events in the establishment of the collagenous framework of the annulus at… Expand
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