Collagen fibrillogenesis: fibronectin, integrins, and minor collagens as organizers and nucleators

@inproceedings{Kadler2008CollagenFF,
  title={Collagen fibrillogenesis: fibronectin, integrins, and minor collagens as organizers and nucleators},
  author={Karl E Kadler and Adele Hill and Elizabeth Gail Canty-Laird},
  booktitle={Current opinion in cell biology},
  year={2008}
}
Collagens are triple helical proteins that occur in the extracellular matrix (ECM) and at the cell-ECM interface. There are more than 30 collagens and collagen-related proteins but the most abundant are collagens I and II that exist as D-periodic (where D = 67 nm) fibrils. The fibrils are of broad biomedical importance and have central roles in embryogenesis, arthritis, tissue repair, fibrosis, tumor invasion, and cardiovascular disease. Collagens I and II spontaneously form fibrils in vitro… CONTINUE READING