Collagen cross-links in mineralizing tissues: a review of their chemistry, function, and clinical relevance.

@article{Knott1998CollagenCI,
  title={Collagen cross-links in mineralizing tissues: a review of their chemistry, function, and clinical relevance.},
  author={Lynda Knott and Allen J. Bailey},
  journal={Bone},
  year={1998},
  volume={22 3},
  pages={181-7}
}
Bone collagen cross-links are now widely used to assess bone resorption levels in many metabolic bone diseases. The post-translational modifications of bone and other mineralizing collagens are significantly different from those of other type I collagen matrices, a fact that has been exploited during recent advances in the development of biochemical markers of bone resorption. The enzymatic collagen cross-linking mechanism is based upon aldehyde formation from specific telopeptide lysine or… CONTINUE READING