Collagen cross-linking but not collagen amount associates with elevated filling pressures in hypertensive patients with stage C heart failure: potential role of lysyl oxidase.

@article{Lpez2012CollagenCB,
  title={Collagen cross-linking but not collagen amount associates with elevated filling pressures in hypertensive patients with stage C heart failure: potential role of lysyl oxidase.},
  author={Bego{\~n}a Soler L{\'o}pez and Ram{\'o}n Querejeta and Arantxa Gonz{\'a}lez and Mariano Larman and Javier D{\'i}ez},
  journal={Hypertension},
  year={2012},
  volume={60 3},
  pages={677-83}
}
We investigated whether the quality of myocardial collagen associates with elevated left-sided filling pressures in 38 hypertensive patients with stage C chronic heart failure. Filling pressures were assessed invasively measuring pulmonary capillary wedge pressure. Left ventricular chamber stiffness constant was calculated from the deceleration time of the early mitral filling wave. The fraction of myocardial volume occupied by total collagen tissue and collagen type I fibers was assessed… CONTINUE READING