Collagen biosynthesis anomalies in prolidase deficiency: effect of glycyl-L-proline on the degradation of newly synthesized collagen.

Abstract

Prolidase deficiency is a rare hereditary disease characterized by an iminodipeptiduria especially composed by glycyl-L-proline which is not further degraded. The study of collagen metabolism in fibroblast cultures from three prolidase-deficient patients showed an increase in the rapidly degraded collagen and a decrease in the proline pool. In order to… (More)

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@article{Chamson1989CollagenBA, title={Collagen biosynthesis anomalies in prolidase deficiency: effect of glycyl-L-proline on the degradation of newly synthesized collagen.}, author={Annette Chamson and Volker Voigtl{\"a}nder and Isaac Myara and J. Foster - Frey}, journal={Clinical physiology and biochemistry}, year={1989}, volume={7 3-4}, pages={128-36} }