Collagen-binding proteoglycan fibromodulin can determine stroma matrix structure and fluid balance in experimental carcinoma.

@article{Oldberg2007CollagenbindingPF,
  title={Collagen-binding proteoglycan fibromodulin can determine stroma matrix structure and fluid balance in experimental carcinoma.},
  author={Ake Oldberg and Sebastian Kalamajski and Alexei V. Salnikov and Linda Elin Birkhaug Stuhr and Matthias M{\"o}rgelin and R. K. Reed and Nils-Erik Heldin and Kristofer Rubin},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2007},
  volume={104 35},
  pages={
          13966-71
        }
}
Research on the biology of the tumor stroma has the potential to lead to development of more effective treatment regimes enhancing the efficacy of drug-based treatment of solid malignancies. Tumor stroma is characterized by distorted blood vessels and activated connective tissue cells producing a collagen-rich matrix, which is accompanied by elevated interstitial fluid pressure (IFP), indicating a transport barrier between tumor tissue and blood. Here, we show that the collagen-binding… CONTINUE READING

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