Collagen-binding integrins as pharmaceutical targets.

@article{Eble2005CollagenbindingIA,
  title={Collagen-binding integrins as pharmaceutical targets.},
  author={Johannes A Eble},
  journal={Current pharmaceutical design},
  year={2005},
  volume={11 7},
  pages={
          867-80
        }
}
In recent years, our understanding of the molecular interaction of collagens with their cognate integrin receptors has remarkably improved. Structural elucidations of both the integrin and the collagenous triple helix have contributed to this achievement. The structures of an entire integrin ectodomain and of an A-domain, which is unique to the integrin alpha subunits of collagen-binding and leukocyte integrins, have been resolved crystallographically. Furthermore, a complex of such an integrin… CONTINUE READING

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