Collagen XXVII Organises the Pericellular Matrix in the Growth Plate

@inproceedings{Plumb2011CollagenXO,
  title={Collagen XXVII Organises the Pericellular Matrix in the Growth Plate},
  author={Darren A. Plumb and Laila Ferrara and T Slavko Torbica and Lynnette Knowles and Aleksandr A Mironov and Karl E Kadler and Michael D. Briggs and Raymond P Boot-Handford},
  booktitle={PloS one},
  year={2011}
}
In order to characterise the function of the novel fibrillar type XXVII collagen, a series of mice expressing mutant forms of the collagen were investigated. Mice harboring a glycine to cysteine substitution in the collagenous domain were phenotypically normal when heterozygote and displayed a mild disruption of growth plate architecture in the homozygous state. Mice expressing an 87 amino acid deletion in the collagenous domain of collagen XXVII were phenotypically normal as heterozygotes… CONTINUE READING
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