Collagen XVII/laminin-5 activates epithelial-to-mesenchymal transition and is associated with poor prognosis in lung cancer

@inproceedings{Liu2018CollagenXA,
  title={Collagen XVII/laminin-5 activates epithelial-to-mesenchymal transition and is associated with poor prognosis in lung cancer},
  author={Chen-Chi Liu and Jiun-Han Lin and Tien-Wei Hsu and Jyuan-Wei Hsu and Jer-Wei Chang and Kelly Su and H. Hsu and Shih-Chieh hung},
  booktitle={Oncotarget},
  year={2018}
}
Epithelial-to-mesenchymal transition (EMT) is associated with tumor metastasis and tumorigenesis in lung cancer stem-like cells (CSCs). However, the exact mechanism underlying this is not clear. We used microarray analysis to identify candidate genes responsible for EMT in spheroid and monolayer cultures of lung cancer cells. We found increased expression of a variety of adhesion molecules in CSCs. One of these molecules, Collagen XVII (Col XVII), was demonstrated to be required for maintenance… CONTINUE READING

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