Collagen VI protects neurons against Aβ toxicity

  title={Collagen VI protects neurons against Aβ toxicity},
  author={Jason Cheng and Dena B. Dubal and Daniel H. Kim and Justin Legleiter and Irene Han-Juo Cheng and G. Yu and Ina Tesseur and Tony Wyss-Coray and Paolo Bonaldo and Lennart Mucke},
  journal={Nature Neuroscience},
Amyloid-β (Aβ) peptides, widely presumed to cause Alzheimer's disease, increased mouse neuronal expression of collagen VI through a mechanism involving transforming growth factor signaling. Reduction of collagen VI augmented Aβ neurotoxicity, whereas treatment of neurons with soluble collagen VI blocked the association of Aβ oligomers with neurons, enhanced Aβ aggregation and prevented neurotoxicity. These results identify collagen VI as an important component of the neuronal injury response… CONTINUE READING

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Nature Neuroscience Volume

  • J. Massagué, J. Seoane, Wotton, D. Genes Dev
  • J. Clin. Invest
  • 2005

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