Collagen Substrate Stiffness Anisotropy Affects Cellular Elongation, Nuclear Shape, and Stem Cell Fate toward Anisotropic Tissue Lineage.

@article{Islam2016CollagenSS,
  title={Collagen Substrate Stiffness Anisotropy Affects Cellular Elongation, Nuclear Shape, and Stem Cell Fate toward Anisotropic Tissue Lineage.},
  author={Anowarul Islam and Mousa Younesi and Thomas S Mbimba and Ozan Akkus},
  journal={Advanced healthcare materials},
  year={2016},
  volume={5 17},
  pages={2237-47}
}
Rigidity of substrates plays an important role in stem cell fate. Studies are commonly carried out on isotropically stiff substrate or substrates with unidirectional stiffness gradients. However, many native tissues are anisotropically stiff and it is unknown whether controlled presentation of stiff and compliant material axes on the same substrate governs… CONTINUE READING