Collagen Specific T-Cell Repertoire and HLA-DR Alleles: Biomarkers of Active Refractory Rheumatoid Arthritis.

@article{Sante2015CollagenST,
  title={Collagen Specific T-Cell Repertoire and HLA-DR Alleles: Biomarkers of Active Refractory Rheumatoid Arthritis.},
  author={Gabriele Di Sante and Barbara Tolusso and Anna Laura Fedele and Elisa Gremese and Stefano Alivernini and Chiara Nicol{\'o} and Francesco Ria and Gianfranco Ferraccioli},
  journal={EBioMedicine},
  year={2015},
  volume={2 12},
  pages={2037-45}
}
Rheumatoid arthritis (RA) is characterized by chronic joint inflammation and associates with HLA-DRB1*04. The Collagen IIp261-273-specific T cell repertoire in the peripheral blood of DR4 + patients at the onset of the disease shows a restricted TCR-beta chain usage among which the most frequent is TRBV25. To define whether this group of DR4-restricted… CONTINUE READING