Collagen IV induces trophoectoderm differentiation of mouse embryonic stem cells.

@article{SchenkeLayland2007CollagenII,
  title={Collagen IV induces trophoectoderm differentiation of mouse embryonic stem cells.},
  author={Katja Schenke-Layland and Ekaterini Angelis and Katrin E Rhodes and Sepideh Heydarkhan-Hagvall and Hanna K. A. Mikkola and W. Robb MacLellan},
  journal={Stem cells},
  year={2007},
  volume={25 6},
  pages={1529-38}
}
The earliest segregation of lineages in the developing embryo is the commitment of cells to the inner cell mass or the trophoectoderm in preimplantation blastocysts. The exogenous signals that control commitment to a particular cell lineage are poorly understood; however, it has been suggested that extracellular "niche" and extracellular matrix, in particular, play an important role in determining the developmental fate of stem cells. Collagen IV (ColIV) has been reported to direct embryonic… CONTINUE READING

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