Collagen I membranes for tendon repair: effect of collagen fiber orientation on cell behavior.

  title={Collagen I membranes for tendon repair: effect of collagen fiber orientation on cell behavior.},
  author={Antonio Pompilio Gigante and Eugenio Cesari and Alberto Busilacchi and Sandra Manzotti and Kyriaki Kyriakidou and Francesco Greco and Roberto Di Primio and Monica Mattioli-Belmonte},
  journal={Journal of orthopaedic research : official publication of the Orthopaedic Research Society},
  volume={27 6},
Tendons have poor spontaneous regenerative capabilities, and complete regeneration is never achieved despite intensive remodeling. In this in vitro study, we characterized two multilamellar collagen I membranes differing in the arrangement of collagen fiber deposition (oriented vs. nonoriented) and compared their mechanical properties. Human dermal fibroblasts and tenocytes were seeded on the two membranes to evaluate the effect of fiber orientation on cell viability and cytoskeletal… CONTINUE READING
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