Collagen I derived recombinant protein microspheres as novel delivery vehicles for bone morphogenetic protein-2.

@article{Mumcuoglu2018CollagenID,
  title={Collagen I derived recombinant protein microspheres as novel delivery vehicles for bone morphogenetic protein-2.},
  author={Didem Mumcuoglu and Laura de Miguel and Shehrazade Jekhmane and Claudia Siverino and Joachim Nickel and Thomas D Mueller and Johannes P T M van Leeuwen and Gerjo van Osch and Sebastiaan G J M Kluijtmans},
  journal={Materials science & engineering. C, Materials for biological applications},
  year={2018},
  volume={84},
  pages={
          271-280
        }
}
Bone morphogenetic protein-2 (BMP-2) is a powerful osteoinductive protein; however, there is a need for the development of a safe and efficient BMP-2 release system for bone regeneration therapies. Recombinant extracellular matrix proteins are promising next generation biomaterials since the proteins are well-defined, reproducible and can be tailored for specific applications. In this study, we have developed a novel and versatile BMP-2 delivery system using microspheres from a recombinant… CONTINUE READING

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