Collagen-GAG substrate enhances the quality of nerve regeneration through collagen tubes up to level of autograft.

@article{Chamberlain1998CollagenGAGSE,
  title={Collagen-GAG substrate enhances the quality of nerve regeneration through collagen tubes up to level of autograft.},
  author={Lyle Chamberlain and Ioannis Vassilios Yannas and H P Hsu and Gary R. Strichartz and Myron Spector},
  journal={Experimental neurology},
  year={1998},
  volume={154 2},
  pages={315-29}
}
Peripheral nerve regeneration was studied across a tubulated 10-mm gap in the rat sciatic nerve using histomorphometry and electrophysiological measurements of A-fiber, B-fiber, and C-fiber peaks of the evoked action potentials. Tubes fabricated from large-pore collagen (max. pore diameter, 22 nm), small-pore collagen (max. pore diameter, 4 nm), and silicone were implanted either saline-filled or filled with a highly porous, collagen-glycosaminoglycan (CG) matrix. The CG matrix was deliberately… CONTINUE READING

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