Collagen Fibril Formation in Vitro

@inproceedings{Gelman2002CollagenFF,
  title={Collagen Fibril Formation in Vitro},
  author={Robert A. Gelman and Donald C. Poppke and Karl A. Piez},
  year={2002}
}
We showed previously that fibril formation in vitro from rat tail tendon collagen requires a temperaturedependent initiation (Step 1) following which linear assembly to form thin filaments (Step 2) proceeds as rapidly at 4°C as at 26°C. Step 3, lateral assembly of filaments to form fibrils, is again temperature-dependent. We now find that Step 1 is complete in 6 min at 26°C and the time is independent of collagen concentration in the range 0.08 to 0.39 mg/ml. Collagen treated with pepsin, which… CONTINUE READING

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