Collagen Complexity Spatially Defines Microregions of Total Tissue Pressure in Pancreatic Cancer

@inproceedings{Nieskoski2017CollagenCS,
  title={Collagen Complexity Spatially Defines Microregions of Total Tissue Pressure in Pancreatic Cancer},
  author={Michael D. Nieskoski and Kayla Marra and Jason R. Gunn and P. Jack Hoopes and Marvin M. Doyley and Tayyaba Hasan and B. Stuart Trembly and Brian W. Pogue},
  booktitle={Scientific Reports},
  year={2017}
}
The poor efficacy of systemic cancer therapeutics in pancreatic ductal adenocarcinoma (PDAC) is partly attributed to deposition of collagen and hyaluronan, leading to interstitial hypertension collapsing blood and lymphatic vessels, limiting drug delivery. The intrinsic micro-regional interactions between hyaluronic acid (HA), collagen and the spatial origins of mechanical stresses that close off blood vessels was investigated here. Multiple localized pressure measurements were analyzed with… CONTINUE READING

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Showing 1-10 of 39 references

An In Vitro Residual Stress Model

Lai, V. K. et al. Swelling of Collagen-Hyaluronic Acid Co-Gels
Ann Biomed Eng 44, 2984–2993, doi:10.1007/s10439-016-1636-0 • 2016

Correlations With Detailed Pathological Findings

Ko, E. S. et al. Assessment of Invasive Breast Cancer Het Analysis
Medicine (Baltimore) 95, e2453, doi:10.1097/MD.0000000000002453 • 2016

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