Collaborative work on evaluation of ovarian toxicity. 13) Two- or four-week repeated dose studies and fertility study of PPAR alpha/gamma dual agonist in female rats.

@article{Sato2009CollaborativeWO,
  title={Collaborative work on evaluation of ovarian toxicity. 13) Two- or four-week repeated dose studies and fertility study of PPAR alpha/gamma dual agonist in female rats.},
  author={Norihiro Sato and Keisuke Uchida and Mikio Nakajima and Atsushi Watanabe and Terutomo Kohira},
  journal={The Journal of toxicological sciences},
  year={2009},
  volume={34 Suppl 1},
  pages={
          SP137-46
        }
}
The main focus of this study was to determine the optimal dosing period in a repeated dose toxicity study based on toxic effects as assessed by ovarian morphological changes. To assess morphological and functional changes induced in the ovary by a peroxisome proliferator-activated receptor (PPAR) alpha/gamma dual agonist, the compound was administered to female rats at dose levels of 0, 4, 20, and 100 mg/kg/day in a repeated dose toxicity study for 2 or 4 weeks, and from 2 weeks prior to mating… CONTINUE READING
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