Collaborative meta-analysis finds no evidence of a strong interaction between stress and 5-HTTLPR genotype contributing to the development of depression

@inproceedings{Culverhouse2017CollaborativeMF,
  title={Collaborative meta-analysis finds no evidence of a strong interaction between stress and 5-HTTLPR genotype contributing to the development of depression},
  author={Robert C. Culverhouse and Nancy L. Saccone and Amy C. Horton and Yinjiao Ma and Kaarin J. Anstey and Tobias Banaschewski and Margit Burmeister and Sarah Cohen-Woods and Bruno Etain and Helen L Fisher and Noreen Goldman and Sebastien Guillaume and John Horwood and Gabriella Juh{\'a}sz and Kathryn J Lester and Laura Mandelli and Christel M Middeldorp and Emilie Oli{\'e} and Sandra M. Villafuerte and Tracy M. Air and Rodolfo Araya and Lindsey Bowes and Richard A Burns and Enda M Byrne and Catherine Judith Coffey and William L Coventry and Katerina A B Gawronski and Dana A Glei and Alex Hatzimanolis and J-J Hottenga and Isabelle Jaussent and C. Kalaiyarasan S. Jawahar and Christine Jennen-Steinmetz and John R Kramer and Mohamed Lajnef and Keriann Little and Henriette E Meyer Zu Schwabedissen and Matthias Nauck and Esther Nederhof and P{\'e}ter Petschner and Wouter J. Peyrot and Christian Schwahn and Grant Sinnamon and David Stacey and Yuting Tian and Catherine Toben and Sandra Van der Auwera and Nigel Wainwright and J-C Wang and Gonneke Willemsen and I. M. Anderson and Volker Arolt and Cecilia {\AA}slund and Gyorgy Bagdy and Bernhard T. Baune and Frank Bellivier and Dorret I. Boomsma and Philippe Courtet and Udo Dannlowski and Eco J C de Geus and J. F. W. Deakin and Simon Easteal and Thalia C Eley and David Fergusson and Alison M. Goate and Xenia Gonda and Hans J{\"o}rgen Grabe and Claudia B Holzman and Eric O. Johnson and Martin A Kennedy and Manfred Laucht and N. G. Martin and Marcus R Munaf{\`o} and Kent W. Nilsson and Albertine J. Oldehinkel and Craig A Olsson and Johan Ormel and Christian Otte and George C. Patton and Brenda W Penninx and Karen Ritchie and Marco Sarchiapone and Jeanette M. Scheid and Alessandro Serretti and Johannes H Smit and Nicholas C. Stefanis and P G Surtees and Henry V{\"o}lzke and Mitchel Weinstein and Mary A Whooley and John I. Nurnberger and Naomi Breslau and Laura J. Bierut},
  booktitle={Molecular Psychiatry},
  year={2017}
}
The hypothesis that the S allele of the 5-HTTLPR serotonin transporter promoter region is associated with increased risk of depression, but only in individuals exposed to stressful situations, has generated much interest, research and controversy since first proposed in 2003. Multiple meta-analyses combining results from heterogeneous analyses have not settled the issue. To determine the magnitude of the interaction and the conditions under which it might be observed, we performed new analyses… CONTINUE READING

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