Collaborative matrix factorization with multiple similarities for predicting drug-target interactions

@inproceedings{Zheng2013CollaborativeMF,
  title={Collaborative matrix factorization with multiple similarities for predicting drug-target interactions},
  author={Xiaodong Zheng and Hao Ding and Hiroshi Mamitsuka and Shanfeng Zhu},
  booktitle={KDD},
  year={2013}
}
We address the problem of predicting new drug-target interactions from three inputs: known interactions, similarities over drugs and those over targets. This setting has been considered by many methods, which however have a common problem of allowing to have only one similarity matrix over drugs and that over targets. The key idea of our approach is to use more than one similarity matrices over drugs as well as those over targets, where weights over the multiple similarity matrices are… CONTINUE READING

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