Colitogenic Bacteroides thetaiotaomicron Antigens Access Host Immune Cells in a Sulfatase-Dependent Manner via Outer Membrane Vesicles.

@article{Hickey2015ColitogenicBT,
  title={Colitogenic Bacteroides thetaiotaomicron Antigens Access Host Immune Cells in a Sulfatase-Dependent Manner via Outer Membrane Vesicles.},
  author={Christina A Hickey and Kristine A Kuhn and David L. Donermeyer and Nathan T. Porter and Chunsheng Jin and Elizabeth A. Cameron and Haerin Jung and Gerard E Kaiko and Marta Wegorzewska and Nicole P Malvin and Robert W P Glowacki and Gunnar C Hansson and Paul E. Allen and Eric C Martens and Thaddeus S Stappenbeck},
  journal={Cell host & microbe},
  year={2015},
  volume={17 5},
  pages={672-80}
}
Microbes interact with the host immune system via several potential mechanisms. One essential step for each mechanism is the method by which intestinal microbes or their antigens access specific host immune cells. Using genetically susceptible mice (dnKO) that develop spontaneous, fulminant colitis, triggered by Bacteroides thetaiotaomicron (B. theta), we investigated the mechanism of intestinal microbial access under conditions that stimulate colonic inflammation. B. theta antigens localized… CONTINUE READING
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