Colistin nephrotoxicity increases with age.

@article{Balkan2014ColistinNI,
  title={Colistin nephrotoxicity increases with age.},
  author={Ilker Inanç Balkan and Mustafa Doğan and Bulent Durdu and Ayşe Batirel and Ismail Necati Hakyemez and Birsen Durmaz Cetin and Oguz Karabay and Ibak Gonen and Ahmet Selim Ozkan and Sami Uzun and Muhammed Emin Demirkol and Sedat Akbaş and Asiye Bahar Kacmaz and Sukru Aras and A. A. Mert and Fehmi Tabak},
  journal={Scandinavian journal of infectious diseases},
  year={2014},
  volume={46 10},
  pages={678-85}
}
BACKGROUND Colistin (COL) has become the backbone of the treatment of infections due to extensively drug-resistant (XDR) Gram-negative bacteria. The most common restriction to its use is acute kidney injury (AKI). METHODS We conducted a retrospective cohort study to evaluate risk factors for new-onset AKI in patients receiving COL. The cohort consisted of 198 adults admitted to 9 referral hospitals between January 2010 and October 2012 and treated with intravenous COL for ≥ 72 h. Patients… CONTINUE READING
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