Colistin-associated Acute Kidney Injury in Severely Ill Patients: A Step Toward a Better Renal Care? A Prospective Cohort Study.

@article{Dalfino2015ColistinassociatedAK,
  title={Colistin-associated Acute Kidney Injury in Severely Ill Patients: A Step Toward a Better Renal Care? A Prospective Cohort Study.},
  author={Lidia Dalfino and Filomena Puntillo and Maria Josephine Mura Ondok and A. M. Luppi Mosca and Rosa Anna Monno and Sara Coppolecchia and Maria Luigia Spada and Francesco Bruno and Nicola Brienza},
  journal={Clinical infectious diseases : an official publication of the Infectious Diseases Society of America},
  year={2015},
  volume={61 12},
  pages={1771-7}
}
BACKGROUND Critically ill patients with severe sepsis or septic shock may need relatively high colistin daily doses for efficacy against multidrug-resistant and extensively drug-resistant gram-negative rods. However, acute kidney injury (AKI) may represent a major dose-limiting adverse effect of colistin. We sought to determine AKI occurrence and to identify factors influencing AKI risk in severely ill patients receiving colistin according to a recently proposed dosing strategy. METHODS A… CONTINUE READING
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Risk factors for acute kidney injury in patients treated with polymyxin B or colistin methasulphonate sodium

  • FF Tuon, MH Rigatto, CK Lopes
  • Int J Antimicrob Agents
  • 2014
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