Colistin Resistant A. baumannii: Genomic and Transcriptomic Traits Acquired Under Colistin Therapy

@article{Cafiso2019ColistinRA,
  title={Colistin Resistant A. baumannii: Genomic and Transcriptomic Traits Acquired Under Colistin Therapy},
  author={Viviana Cafiso and Stefano Stracquadanio and Flavia Lo Verde and Giacoma Gabriele and Maria Lina Mezzatesta and Carla Caio and Giuseppe Pigola and Alfredo Ferro and Stefania Stefani},
  journal={Frontiers in Microbiology},
  year={2019},
  volume={9}
}
Even though colistin-based treatment represents the antimicrobial-regimen backbone for the management of multidrug-resistant Gram-negative infections, colistin resistance is still rare, at least as a full resistance, in Acinetobacter baumannii (Ab). We investigated the genomics and transcriptomics of two clinical Extensively Drug Resistance (XDR) colistin-susceptible/resistant (COL-S/R) Ab strain-pairs in which COL-resistance was developed after exposure to colistin therapy. The molecular… Expand
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