Colistin: an update on the antibiotic of the 21st century.

  title={Colistin: an update on the antibiotic of the 21st century.},
  author={Silpak Biswas and Jean-Michel Brunel and Jean-Christophe Dubus and Martine Reynaud-Gaubert and Jean Marc Rolain},
  journal={Expert review of anti-infective therapy},
  volume={10 8},
The emergence of multidrug-resistant Gram-negative bacteria that cause nosocomial infections is a growing problem worldwide. Colistin was first introduced in 1952 and was used until the early 1980s for the treatment of infections caused by Gram-negative bacilli. In vitro, colistin has demonstrated excellent activity against various Gram-negative rod-shaped bacteria, including multidrug-resistant Pseudomonas aeruginosa, Acinetobacter baumannii and Klebsiella pneumoniae. Recent clinical findings… CONTINUE READING

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