Colistin, mechanisms and prevalence of resistance

  title={Colistin, mechanisms and prevalence of resistance},
  author={Abed Zahedi Bialvaei and Hossein Samadi kafil},
  journal={Current Medical Research and Opinion},
  pages={707 - 721}
Abstract Background: Infections caused by multi-drug-resistant Gram-negative bacteria, particularly Acinetobacter baumannii, Pseudomonas aeruginosa and Klebsiella pneumoniae, that cause nosocomial infections, represent a growing problem worldwide. The rapid increase in the prevalence of Gram-negative pathogens that are resistant to fluoroquinolones and aminoglycosides as well as all β-lactams, including carbapenems, monobactam, cephalosporins and broad-spectrum penicillins, has prompted the… 

Colistin and its role in the Era of antibiotic resistance: an extended review (2000–2019)

This review intends to discuss the progress over the last two decades in understanding the alternative colistin mechanisms of action and different strategies used by bacteria to develop resistance againstcolistin, besides providing an update about what is previously recognized and what is novel concerning colistsin resistance.

An Update of Mobile Colistin Resistance in Non-Fermentative Gram-Negative Bacilli

This review focuses on the most recent update on colistin resistance and the epidemiology of mcr genes among non-fermentative Gram-negative bacilli, especially Acinetobacter spp.

Analysis of the prevalence of colistin resistance among clinical strains of Klebsiella pneumoniae

Although a low rate of CL resistance was observed, this was true for strains simultaneously producing carbapenemases, and such strains should be under special epidemiological surveillance due to their potential to cause epidemic outbreaks.

Molecular mechanisms related to colistin resistance in Enterobacteriaceae

Current knowledge about the different mechanisms of colistin resistance is presented and clinicians should be alert to the possibility of colistsin resistance among multidrug-resistant bacteria and development through mutation or adaptation mechanisms.


Introduction: Multi-drug resistant (MDR) P. aeruginosa is constantly increasing and causing severe issues in combatting widely spread health problems. The aim of this study was to assess colistin

Epidemiology of colistin-resistant, carbapenemase-producing Enterobacteriaceae and Acinetobacter baumannii in Croatia.

Colistin: Mechanisms of antibiotic resistance and logical approach to its use

  • Fariba Lahoorpour
  • Medicine, Biology
    Scientific Journal of Kurdistan University of Medical Sciences
  • 2021
Background and Aim: In recent decades, widespread antibiotic resistance in nosocomial infections due to gram-negative bacteria which can cause high mortality rates have significantly increased,

Synergistic Antimicrobial Effect of Colistin in Combination with Econazole against Multidrug-Resistant Acinetobacter baumannii and Its Persisters

Econazole and colistin can act synergistically to produce a strong antimicrobial effect sufficient for eradication of starvation-induced tolerant and multidrug-resistant populations of Acinetobacter baumannii, a notorious pathogen causing recalcitrant infections, both in vitro and in mouse infection models.

The Antimicrobial Peptide Esc(1-21) Synergizes with Colistin in Inhibiting the Growth and in Killing Multidrug Resistant Acinetobacter baumannii Strains

This study characterized the activity and the membrane-perturbing mechanism of bactericidal action of a derivative of a frog-skin AMP, namely Esc(1-21), when used alone or in combination with colistin against multidrug-resistant A. baumannii clinical isolates and found that the mixture of the two compounds had a synergistic effect in inhibiting the growth and killing of all of the tested strains.

Colistin Resistance among Enterobacteriaceae Isolated from Clinical Samples in Gaza Strip

The main objective of this study was to investigate the presence of colistin resistance among clinical GNB isolated from Gaza Strip hospitals and found the overall resistance to colist in was high (41%) among tested clinical isolates.



Colistin: the revival of polymyxins for the management of multidrug-resistant gram-negative bacterial infections.

  • M. FalagasS. Kasiakou
  • Biology, Medicine
    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
  • 2005
Recent studies of patients who received intravenous polymyxins for the treatment of serious P. aeruginosa and Acinetobacter baumannii infections of various types, including pneumonia, bacteremia, and urinary tract infections, have led to the conclusion that these antibiotics have acceptable effectiveness and considerably less toxicity than was reported in old studies.

Polymyxin B for the treatment of multidrug-resistant pathogens: a critical review.

Since polymyxins will be increasingly used for the treatment of infections caused by MDR bacteria, clinical pharmacokinetic, pharmacodynamic and toxicodynamic studies underpinning the optimal use of these drugs are urgently required.

Colistin Resistance in Acinetobacter baumannii Is Mediated by Complete Loss of Lipopolysaccharide Production

It is shown that A. baumannii can rapidly develop resistance to polymyxin antibiotics by complete loss of the initial binding target, the lipid A component of lipopolysaccharide (LPS), which has long been considered to be essential for the viability of Gram-negative bacteria.

Investigation of colistin sensitivity via three different methods in Acinetobacter baumannii isolates with multiple antibiotic resistance

Summary Background: In recent years there has been an increase in life-threatening infections caused by Acinetobacter baumannii with multiple antibiotic resistance, which has lead to the use of

In Vitro Interaction of Colistin and Rifampin on Multidrug-Resistant Pseudomonas aeruginosa

It is concluded that colistin and rifampin express a considerable In Vitro synergistic effect on multidrugresistant P. aeruginosa.

Polymyxin B Sulfate and Colistin: Old Antibiotics for Emerging Multiresistant Gram-Negative Bacteria

The polymyxin B and colistin are recommended for serious systemic infections caused by gram-negative bacteria that are resistant to other agents and have a role in the therapy of multidrug-resistant gram- negative bacterial infections.

Therapy of Infections due to Carbapenem-Resistant Gram-Negative Pathogens

Containment ofCRGNs should be pursued through implementation of adequate infection prevention procedures and antimicrobial stewardship to reduce the disease burden and prevent future outbreaks of CRGNs.