Coley's toxins in perspective

  title={Coley's toxins in perspective},
  author={Charlie O. Starnes},
Despite initial hopes, the efficacy of tumour necrosis factor in treating cancer patients has been disappointing. But a more careful selection of patients, and more appropriate treatment, might be fruitful. 
Lessons from Coley's Toxin.
Potential Immunotherapy for Tuberculosis and Future Potential for HIV
The history of immunotherapy for tuberculosis is reviewed, some new data supportive of a view that correcting the immune abnormality of tuberculosis could be a model for the correction of that of HIV are described.
Modulating Organ Dysfunction in Experimental Septic Shock : Effects of Aminoglycosides, Antiendotoxin Measures and Endotoxin Tolerance
A systemic inflammatory reaction underlying the development of septic organ dysfunction can be modele-like, leading to sepsis and high mortality in the intensive care population.
Tumour necrosis factor and cancer
Tumour necrosis factor (TNF) is a major inflammatory cytokine that was first identified for its ability to induce rapid haemorrhagic necrosis of experimental cancers. When efforts to harness this
Potential of DMXAA combination therapy for solid tumors
DMXAA is one of the first examples of a new class of anticancer agents that attack existing tumor blood vessels and thus deprives tumor tissue of an adequate blood supply. Its mechanism of action
Immunotherapy in acute leukemia.
  • W. Leung
  • Medicine
    Seminars in hematology
  • 2009
The latest concepts in antitumor immunology and its application in the treatment of cancer, with particular focus on acute leukemia are reviewed.
Fever and cancer in perspective
  • U. Hobohm
  • Medicine
    Cancer Immunology, Immunotherapy
  • 2001
Fever induction under medical guidance may be considered as part of a therapy regimen for cancers of mesodermal origin and William Coley's seminal work about the putative anti-cancer effect of fever is brought together.
Paradigm Shifts in Perspective III: The Discovery of Tumor Necrosis Factor
  • J. Kaunitz
  • Medicine
    Digestive Diseases and Sciences
  • 2014
A discovery of immense impact on the field of gastroenterology, but also of enormous importance to the therapy of chronic inflammatory conditions and also to tumor immunology— namely, the discovery of tumor necrosis factor (TNF), as first reported by Carswell et al. in 1975.
The toxins of William B. Coley and the treatment of bone and soft-tissue sarcomas.
William B. Coley, a bone sarcoma surgeon, deserves the title "Father of Immunotherapy", because the modern science of immunology has shown that Coley's principles were correct and that some cancers are sensitive to an enhanced immune system.


Effect of the mixed bacterial vaccine on the immune response of patients with non‐small cell lung cancer and refractory malignancies
In this pilot study, cancer patients treated with MBV showed objective evidence of immune stimulation with acceptable toxicity, and some patients, B‐cells and helper T‐cell populations increased, whereas T‐suppressor cell numbers declined.
A phase I trial of recombinant human tumor necrosis factor and interferon-gamma: effects of combination cytokine administration in vivo.
The addition of interferon-gamma to TNF resulted in a greater than three-fold increase in toxicity compared with TNF administered as a single agent, supporting the hypothesis that the combination of these cytokines may induce synergistic effects in vivo.
The immunological basis of endotoxin-induced tumor regression. Requirement for a pre-existing state of concomitant anti-tumor immunity
It was shown that of four syngeneic, murine tumors investigated, only those that evoked the generation of a state of concomitant anti-tumor immunity were susceptible to endotoxin-induced regression, which points to the likely possibility that tumor regression depends on the preceding acquisition of the specifically-sensitized, effector T cells that express conComitant immunity.
An endotoxin-induced serum factor that causes necrosis of tumors.
It is proposed that TNF mediates endotoxin-induced tumor necrosis, and that it may be responsible for the suppression of transformed cells by activated macrophages.