Coley's toxins in perspective

@article{Starnes1992ColeysTI,
  title={Coley's toxins in perspective},
  author={Charlie O. Starnes},
  journal={Nature},
  year={1992},
  volume={357},
  pages={11-12}
}
Despite initial hopes, the efficacy of tumour necrosis factor in treating cancer patients has been disappointing. But a more careful selection of patients, and more appropriate treatment, might be fruitful. 
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References

SHOWING 1-5 OF 5 REFERENCES
Effect of the mixed bacterial vaccine on the immune response of patients with non‐small cell lung cancer and refractory malignancies
TLDR
In this pilot study, cancer patients treated with MBV showed objective evidence of immune stimulation with acceptable toxicity, and some patients, B‐cells and helper T‐cell populations increased, whereas T‐suppressor cell numbers declined.
A phase I trial of recombinant human tumor necrosis factor and interferon-gamma: effects of combination cytokine administration in vivo.
TLDR
The addition of interferon-gamma to TNF resulted in a greater than three-fold increase in toxicity compared with TNF administered as a single agent, supporting the hypothesis that the combination of these cytokines may induce synergistic effects in vivo.
The immunological basis of endotoxin-induced tumor regression. Requirement for a pre-existing state of concomitant anti-tumor immunity
TLDR
It was shown that of four syngeneic, murine tumors investigated, only those that evoked the generation of a state of concomitant anti-tumor immunity were susceptible to endotoxin-induced regression, which points to the likely possibility that tumor regression depends on the preceding acquisition of the specifically-sensitized, effector T cells that express conComitant immunity.
An endotoxin-induced serum factor that causes necrosis of tumors.
TLDR
It is proposed that TNF mediates endotoxin-induced tumor necrosis, and that it may be responsible for the suppression of transformed cells by activated macrophages.